The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients.

ABSTRACT: Antimicrobial resistant lower respiratory tract infections are an increasing public health threat and an important cause of global mortality. The lung microbiome can influence susceptibility of respiratory tract infections and represents an important reservoir for exchange of antimicrobial resistance genes. Studies of the gut microbiome have found an association between age and increasing antimicrobial resistance gene burden, however, corollary studies in the lung microbiome remain absent. We performed an observational study of children and adults with acute respiratory failure admitted to the intensive care unit. From tracheal aspirate RNA sequencing data, we evaluated age-related differences in detectable antimicrobial resistance gene expression in the lung microbiome. Using a multivaria

SUBMITTER: Chu VT 

PROVIDER: S-EPMC10762195 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature