Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram-Negative Bloodstream Infections.

ABSTRACT:

Importance

Management of gram-negative bloodstream infections (GN-BSIs) with oral antibiotics is highly variable.

Objective

To examine the transition from intravenous (IV) to oral antibiotics, including selection, timing, and associated clinical and microbial characteristics, among hospitalized patients with GN-BSIs.

Design, setting, and participants

A retrospective cohort study was conducted of 4581 hospitalized adults with GN-BSIs at 24 US hospitals between January 1 and December 31, 2019. Patients were excluded if they died within 72 hours. Patients were excluded from the oral therapy group if transition occurred after day 7. Statistical analysis was conducted from July 2022 to October 2023.

Exposures

Administration of antibiotics for GN-BSIs.

Main outcom

SUBMITTER: Engers DW 

PROVIDER: S-EPMC10762571 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature