BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period.

ABSTRACT: The seat of human intelligence is the human cerebral cortex, which is responsible for our exceptional cognitive abilities. Identifying principles that lead to the development of the large-sized human cerebral cortex will shed light on what makes the human brain and species so special. The remarkable increase in the number of human cortical pyramidal neurons and the size of the human cerebral cortex is mainly because human cortical radial glial cells, primary neural stem cells in the cortex, generate cortical pyramidal neurons for more than 130 days, whereas the same process takes only about 7 days in mice. The molecular mechanisms underlying this difference are largely unknown. Here, we found that bone morphogenic protein 7 (BMP7) is expressed by increasing the number of cortical radial gl

SUBMITTER: Li Z 

PROVIDER: S-EPMC10762677 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature