Circulating microRNAs as biomarkers of Chagas cardiomyopathy.

ABSTRACT:

Background

Chagas cardiomyopathy (CHCM) is the most important clinical manifestation of Chagas disease. The analysis of cardiac miRNAs may contribute to predicting the progression to CHCM in Chagas indeterminate phase and/or to the differential diagnosis for cardiomyopathy.

Methods

We carried out a case-control study to identify circulating miRNAs associated with CHCM. We assigned 104 participants to four groups: healthy controls (HC), Chagas non-cardiomyopathy controls, CHCM cases, and ischemic cardiomyopathy controls. We performed a clinical, echocardiographic, and laboratory evaluation and profiled circulating miRNA in the serum samples.

Results

Differences between groups were observed in clinical variables and in the analysis of miRNAs. Compared to HC, CHCM partic

SUBMITTER: Antonietti L 

PROVIDER: S-EPMC10762800 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature