Exogenous glutathione reverses meropenem resistance in carbapenem-resistant Klebsiella pneumoniae.

ABSTRACT: Background: The rate of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection has been increasing rapidly worldwide and, poses a significant risk to human health. Effective methods are urgently needed to address treatment failures related to antibiotic resistance. Recent research has reported that some drugs in combination with antibiotics have displayed synergistic killing of resistant bacteria. Here, we investigated whether glutathione (GSH) can synergize with meropenem, and enhance its effectiveness against CRKP. Methods: Synergistic activity was assessed by checkerboard and time-killing assays. The mechanism of these combinations was assessed by total ROS and membrane permeability assays. The bacterial metabolites were assessed by LC‒MS/MS. Results: Th

SUBMITTER: Yi J 

PROVIDER: S-EPMC10762803 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature