Light-enhanced VEGF₁₂₁/rGel induce immunogenic cell death and increase the antitumor activity of αCTLA4 treatment.

ABSTRACT:

Background

Immune-checkpoint inhibitors (ICIs) represent a revolution in cancer therapy and are currently implemented as standard therapy within several cancer indications. Nevertheless, the treatment is only effective in a subset of patients, and immune-related adverse effects complicate the improved survival. Adjuvant treatments that can improve the efficacy of ICIs are highly warranted, not only to increase the response rate, but also to reduce the therapeutic ICI dosage. Several treatment modalities have been suggested as ICI adjuvants including vascular targeted treatments and photodynamic therapy (PDT). Photochemical internalization (PCI) is a drug delivery system, based on PDT. PCI is long known to generate an immune response in murine models and was recently shown to enhanc

SUBMITTER: Longva AS 

PROVIDER: S-EPMC10762878 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature