DisoFLAG: accurate prediction of protein intrinsic disorder and its functions using graph-based interaction protein language model.

ABSTRACT: Intrinsically disordered proteins and regions (IDPs/IDRs) are functionally important proteins and regions that exist as highly dynamic conformations under natural physiological conditions. IDPs/IDRs exhibit a broad range of molecular functions, and their functions involve binding interactions with partners and remaining native structural flexibility. The rapid increase in the number of proteins in sequence databases and the diversity of disordered functions challenge existing computational methods for predicting protein intrinsic disorder and disordered functions. A disordered region interacts with different partners to perform multiple functions, and these disordered functions exhibit different dependencies and correlations. In this study, we introduce DisoFLAG, a computational method tha

SUBMITTER: Pang Y 

PROVIDER: S-EPMC10762911 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature