Genetic proxies for antihypertensive drugs and mental disorders: Mendelian randomization study in European and East Asian populations.

ABSTRACT:

Background

Mental disorders are among the top causes of disease burden worldwide. Existing evidence regarding the repurposing of antihypertensives for mental disorders treatment is conflicting and cannot establish causation.

Methods

We used Mendelian randomization to assess the effects of angiotensin-converting-enzyme inhibitors (ACEIs), beta blockers (BBs), and calcium channel blockers (CCBs) on risk of bipolar disorder (BD), major depression disorder (MDD), and schizophrenia (SCZ). We used published genetic variants which are in antihypertensive drugs target genes and correspond to systolic blood pressure (SBP) in Europeans and East Asians, and applied them to summary statistics of BD (cases = 41,917; controls = 371,549 in Europeans), MDD (cases = 170,756; controls = 329,4

SUBMITTER: Fan B 

PROVIDER: S-EPMC10763027 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature