External validation of predictive models of sexual, urinary, bowel and hormonal function after surgery in prostate cancer subjects.

ABSTRACT:

Background

In 2020, a research group published five linear longitudinal models, predict Expanded Prostate Cancer Index Composite-26 (EPIC-26) scores post-treatment for radical prostatectomy, external beam radiotherapy and active surveillance collectively in US patients with localized prostate cancer.

Methods

Our study externally validates the five prediction models for patient reported outcomes post-surgery for localised prostate cancer. The models' calibration, fit, variance explained and discrimination (concordance-indices) were assessed. Two Australian validation cohorts 1 and 2 years post-prostatectomy were constructed, consisting of 669 and 439 subjects, respectively (750 in total). Patient reported function in five domains post-prostatectomy: sexual, bowel, hormonal, u

SUBMITTER: Borg MA 

PROVIDER: S-EPMC10763035 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature