Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder.

ABSTRACT: Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is known to disturb circadian rhythms in humans and animals. DEC1, a basic helix-loop-helix transcription factor, plays an important role in the circadian rhythm, inflammation, immune responses, and tumor progression. We have previously shown that Dec1 deficiency inhibits stresses such as periodontal inflammation and perivascular fibrosis of the heart. However, the significance of Dec1 deficiency in chronic alcohol consumption remains unclear. In the present study, we investigated whether the biological stress caused by chronic alcohol intake is inhibited in Dec1 knockout mice. We treated control and Dec1 knockout mice for three months by providin

SUBMITTER: Sato F 

PROVIDER: S-EPMC10763066 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature