Exposure to cadmium and lead is associated with diabetic kidney disease in diabetic patients.

ABSTRACT:

Background

Cadmium (Cd) and lead (Pb) exhibit nephrotoxic activity and may accelerate kidney disease complications in diabetic patients, but studies investigating the relation to diabetic kidney disease (DKD) have been limited. We aimed to examine the associations of Cd and Pb with DKD in diabetic patients.

Methods

3763 adults with blood metal measurements and 1604 adults with urinary ones who were diabetic from National Health and Nutrition Examination Survey (NHANES) 2007-2016 were involved. Multivariate logistic regression models were used to analyze the associations of blood Cd (BCd), blood Pb (BPb), urinary Cd (UCd), and urinary Pb (UPb) with DKD.

Results

BPb, BCd, and UCd levels were higher among participants with DKD than diabetics without nephropathy, but UPb

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10763104 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature