Circulating inflammatory biomarkers and risk of intracranial aneurysm: a Mendelian randomization study.

ABSTRACT:

Background

Intracranial aneurysm (IA) accounts for a substantial source of non-traumatic subarachnoid hemorrhage, with inflammation postulated as a potential factor in its pathogenesis. The present study aims at evaluating the association between circulating inflammatory cytokines and risk of IA under a bidirectional two-sample Mendelian randomization (MR) design.

Methods

For primary analysis, summary statistics of inflammatory regulators was obtained from a genome-wide association study (GWAS) comprising 8293 Finnish participants. Summary data of IA were extracted from a GWAS which comprised 7495 cases and 71,934 controls in European descent. For targeted analysis, summary statistics were extracted from two proteomic studies, which recruit 3301 and 5368 European participant

SUBMITTER: Fang J 

PROVIDER: S-EPMC10763118 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature