Clinical impact of ampulla of Vater cancer subtype classification based on immunohistochemical staining.

ABSTRACT:

Background

The histological subtype is an important prognostic factor for ampulla of Vater (AoV) cancer. This study proposes a classification system for the histological subtyping of AoV cancer based on immunohistochemical (IHC) staining and its prognostic significance.

Methods

Seventy-five AoV cancers were analyzed for cytokeratin 7 (CK7), CK20, and causal-type homeobox transcription factor 2 (CDX2) expression by IHC staining. We differentiated the subtypes (INT, intestinal; PB, pancreatobiliary; MIX, mixed; NOS, not otherwise specified) into classification I: CK7/CK20, classification II: CK7/CK20 or CDX2, classification III: CK7/CDX2 and examined their associations with clinicopathological factors.

Results

Classifications I, II, and III subtypes were INT (7, 10, and

SUBMITTER: Kwon CH 

PROVIDER: S-EPMC10763163 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature