BRCA1 and BRCA2 germline mutations in Chinese Hakka breast cancer patients.

ABSTRACT:

Objective

To investigate the prevalence of BRCA1/2 gene variants and evaluate the clinical and pathological characteristics associated with these variants in Chinese Hakka breast cancer patients.

Methods

A total of 409 breast cancer patients were analyzed based on next-generation sequencing results, with 337 categorized as non-carriers and 72 as carriers of BRCA1/2 variants. Data on the patients' BRCA1/2 gene mutation status, clinical and pathological characteristics, as well as menstrual and reproductive information, were collected, analyzed, compared, and tabulated. Logistic regression analysis was performed to explore the relationship between clinical characteristics and pathogenic variants.

Results

Among the patients, 72 were identified as carriers of pathogenic o

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10763220 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature