Multifunctional Fe-based coordination polymer nano-bomb modified with β-lapachone and CaO₂ for targeted tumor dual chemodynamic therapy with enhanced ferroptosis and H₂O₂ self-supply.

ABSTRACT: Chemodynamic therapy (CDT) is seriously limited by the inadequacy of exogenous catalytic ions and endogenous H₂O₂ in tumors. Herein, a multifunction nano-bomb integrated with calcium peroxide (CaO₂) and β-lapachone as donors of H₂O₂ and GSH-sensitive Fe-based coordination polymer as provider of catalytic ions was constructed for dual cascade-amplified tumor CDT. This hyaluronic acid (HA)-modified nano-bomb could be specially endocytosed by breast cancer cells through a targeting pathway, degraded and released cargoes in response to the GSH-rich cytoplasm. Furthermore, the released CaO₂ and β-lapachone could significantly self-generated sufficient H₂O₂, which could dual-cascade amplify CDT and induce sev

SUBMITTER: Zhao P 

PROVIDER: S-EPMC10763286 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature