TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.

ABSTRACT:

Background

Tandem C2 domains, nuclear (TC2N) is a C2 domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem C2 protein family, and acts as an oncogenic driver in several cancers. Previously, we preliminarily reported that TC2N mediates the PI3K-Akt signaling pathway to inhibit tumor growth of breast cancer (BC) cells. Beyond that, its precise biological functions and detailed molecular mechanisms in BC development and progression are not fully understood.

Methods

Tumor tissues of 212 BC patients were subjected to tissue microarray and further assessed the associations of TC2N expression with pathological parameters and FASN expression. The protein levels of TC2N and FASN in cell lines and tumor specimens were monitored by qRT-PCR, WB, immunofluo

SUBMITTER: Hao XL 

PROVIDER: S-EPMC10763294 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature