Methanol bioconversion into C3, C4, and C5 platform chemicals by the yeast Ogataea polymorpha.

ABSTRACT:

Background

One carbon (C1) molecules such as methanol have the potential to become sustainable feedstocks for biotechnological processes, as they can be derived from CO₂ and green hydrogen, without the need for arable land. Therefore, we investigated the suitability of the methylotrophic yeast Ogataea polymorpha as a potential production organism for platform chemicals derived from methanol. We selected acetone, malate, and isoprene as industrially relevant products to demonstrate the production of compounds with 3, 4, or 5 carbon atoms, respectively.

Results

We successfully engineered O. polymorpha for the production of all three molecules and demonstrated their production using methanol as carbon source. We showed that the metabolism of O. polymorpha is well sui

SUBMITTER: Wefelmeier K 

PROVIDER: S-EPMC10763331 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature