WD repeat domain 76 predicts poor prognosis in lower grade glioma and provides an original target for immunotherapy.

ABSTRACT:

Background

The WD40 repeat (WDR) domain provides scaffolds for numerous protein-protein interactions in multiple biological processes. WDR domain 76 (WDR76) has complex functionality owing to its diversified interactions; however, its mechanism in LGG has not yet been reported.

Methods

Transcriptomic data from public databases were multifariously analyzed to explore the role of WDR76 in LGG pathology and tumor immunity. Laboratory experiments were conducted to confirm these results.

Results

The results first confirmed that high expression of WDR76 in LGG was not only positively associated with clinical and molecular features of malignant LGG, but also served as an independent prognostic factor that predicted shorter survival in patients with LGG. Furthermore, high exp

SUBMITTER: Cheng X 

PROVIDER: S-EPMC10763342 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature