Functional connectivity associated with improvement in emotion management after cognitive enhancement therapy in early-course schizophrenia.

ABSTRACT:

Background

The ability to manage emotions is an important social-cognitive domain impaired in schizophrenia and linked to functional outcome. The goal of our study was to examine the impact of cognitive enhancement therapy (CET) on the ability to manage emotions and brain functional connectivity in early-course schizophrenia.

Methods

Participants were randomly assigned to CET (n = 55) or an enriched supportive therapy (EST) control group (n = 45). The resting-state functional magnetic resonance imaging scans and measures of emotion management performances were collected at baseline, 9, and 18 months follow-up. The final sample consisted of 37 CET and 25 EST participants, including 19 CET and 12 EST participants with imaging data. Linear mixed-effects models inv

SUBMITTER: Guimond S 

PROVIDER: S-EPMC10763577 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature