Exogenous corticosterone administration during pregnancy in mice alters placental and fetal thyroid hormone availability in females.

ABSTRACT:

Introduction

Maternal prenatal psychological stress is associated with adverse pregnancy outcomes and increased risk of adverse health outcomes in children. While the molecular mechanisms that govern these associations has not been fully teased apart, stress-induced changes in placental function can drive sex-specific phenotypes in offspring. We sought to identify and examine molecular pathways in the placenta that are altered in response to maternal prenatal stress.

Methods

We previously employed a mouse model of maternal prenatal stress where pregnant dams were treated with stress hormone (CORT) beginning in mid-gestation. Using this model, we conducted RNAseq analysis of whole placenta at E18.5. We used qRT-PCR to validate gene expression changes in the placenta and in a

SUBMITTER: Paul EN 

PROVIDER: S-EPMC10763606 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature