Molecular traces of Drosophila hemocytes reveal transcriptomic conservation with vertebrate myeloid cells.

ABSTRACT: Drosophila hemocytes serve as the primary defense system against harmful threats, allowing the animals to thrive. Hemocytes are often compared to vertebrate innate immune system cells due to the observed functional similarities between the two. However, the similarities have primarily been established based on a limited number of genes and their functional homologies. Thus, a systematic analysis using transcriptomic data could offer novel insights into Drosophila hemocyte function and provide new perspectives on the evolution of the immune system. Here, we performed cross-species comparative analyses using single-cell RNA sequencing data from Drosophila and vertebrate immune cells. We found several conserved markers for the cluster of differentiation (CD) genes in Drosophila hemocytes and

SUBMITTER: Yoon SH 

PROVIDER: S-EPMC10763942 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature