Ontology highlight
ABSTRACT:
SUBMITTER: Jung BC
PROVIDER: S-EPMC10763978 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Jung Byung Chul BC You Dongjoo D Lee Ikjun I Li Daofeng D Schill Rebecca L RL Ma Katherine K Pi Anna A Song Zehan Z Mu Wei-Chieh WC Wang Ting T MacDougald Ormond A OA Banks Alexander S AS Kang Sona S
Cell reports 20230930 10
Maintaining healthy adipose tissue is crucial for metabolic health, requiring a deeper understanding of adipocyte development and response to high-calorie diets. This study highlights the importance of TET3 during white adipose tissue (WAT) development and expansion. Selective depletion of Tet3 in adipose precursor cells (APCs) reduces adipogenesis, protects against diet-induced adipose expansion, and enhances whole-body metabolism. Transcriptomic analysis of wild-type and Tet3 knockout (KO) APC ...[more]