Exploration of Metabolomic Markers Associated With Declining Kidney Function in People With Type 2 Diabetes Mellitus.

ABSTRACT:

Background

Metabolomics, the study of small molecules in biological systems, can provide valuable insights into kidney dysfunction in people with type 2 diabetes mellitus (T2DM), but prospective studies are scarce. We investigated the association between metabolites and kidney function decline in people with T2DM.

Methods

The Edinburgh Type 2 Diabetes Study, a population-based cohort of 1066 men and women aged 60 to 75 years with T2DM. We measured 149 serum metabolites at baseline and investigated individual associations with baseline estimated glomerular filtration rate (eGFR), incident chronic kidney disease [CKD; eGFR <60 mL/min/(1.73 m)²], and decliner status (5% eGFR decline per year).

Results

At baseline, mean eGFR was 77.5 mL/min/(1.73 m)²

SUBMITTER: Krasauskaite J 

PROVIDER: S-EPMC10763986 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature