Association of Vitamin D with Severity and Outcome of COVID-19: Clinical and Experimental Evidence.

ABSTRACT:

Introduction

The role of vitamin in COVID-19 remains controversial. We investigated the association between endogenous vitamin D and the severity of COVID-19 as well as the mechanisms of action of vitamin D supplementation.

Methods

25(OH)D3 in serum was associated with disease severity and outcome in 190 COVID-19 patients. In a COVID-19 animal model using intravenous injection of plasma from patients with COVID-19 acute respiratory distress syndrome into C57/BL6 mice, mice were treated with 0.25 μg human 1,25(OH)D3 or vehicle. Mice were sacrificed on day 4. Cytokines and myeloperoxidase (MPO) in tissues were measured. Changes in gene expression after vitamin D supplementation were measured.

Results

Vitamin D deficiency and insufficiency were associated with increased

SUBMITTER: Renieris G 

PROVIDER: S-EPMC10764091 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature