The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy.

ABSTRACT: Gene and protein expressions display circadian oscillations, which can be disrupted in diseases in most body organs. Whether these oscillations occur in the healthy hippocampus and whether they are altered in epilepsy are not known. We identified more than 1200 daily oscillating transcripts in the hippocampus of control mice and 1600 in experimental epilepsy, with only one-fourth oscillating in both conditions. Comparison of gene oscillations in control and epilepsy predicted time-dependent alterations in energy metabolism, which were verified experimentally. Although aerobic glycolysis remained constant from morning to afternoon in controls, it increased in epilepsy. In contrast, oxidative phosphorylation increased in control and decreased in epilepsy. Thus, the control hippocampus shows

SUBMITTER: Debski KJ 

PROVIDER: S-EPMC10764101 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature