Biooriented Synthesis of Ibuprofen-Clubbed Novel Bis-Schiff Base Derivatives as Potential Hits for Malignant Glioma: In Vitro Anticancer Activity and In Silico Approach.

ABSTRACT: This research work is based on the synthesis of bis-Schiff base derivatives of the commercially available ibuprofen drug in outstanding yields through multistep reactions. Structures of the synthesized compounds were confirmed by the help of modern spectroscopic techniques including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), ¹H NMR, and ¹³C NMR. The synthesized compounds were evaluated for their anticancer activity using a normal human embryonic kidney HEK293 cell and U87-malignant glioma (ATCC-HTB-14) as a cancer cell line. All of the synthesized compounds among the series exhibited excellent to less antiproliferative activity having IC₅₀ values ranging from 5.75 ± 0.43 to 150.45 ± 0.20 μM. Among them, compound 5e

SUBMITTER: Ayaz M 

PROVIDER: S-EPMC10764114 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature