Investigational treatment strategies in glioblastoma: progress made and barriers to success.

ABSTRACT:

Introduction

Glioblastoma, isocitrate dehydrogenase wildtype (IDHwt), remains an incurable disease despite considerable research effort. The current standard of care since 2005 comprises maximal safe resection followed by radiation with concurrent and adjuvant temozolomide; more recently, the addition of tumor treating fields was approved in the newly diagnosed and recurrent disease settings.

Areas covered

Searches of PubMed, Cochrane Library, and ClinicalTrials.gov provided a foundation for this review. We first describe early research including carmustine wafers, brachytherapy, anti-angiogenesis, and immune checkpoint inhibition for glioblastoma. Next, we discuss challenges precluding the translation of preclinical successes. This is followed by a description of promising

SUBMITTER: Nelson TA 

PROVIDER: S-EPMC10764117 | biostudies-literature | 2023 Jul-Dec

REPOSITORIES: biostudies-literature