Ketamine for postoperative avoidance of depressive symptoms: the K-PASS feasibility randomised trial.

ABSTRACT:

Background

Surgical patients with previous depression frequently experience postoperative depressive symptoms. This study's objective was to determine the feasibility of a placebo-controlled trial testing the impact of a sustained ketamine infusion on postoperative depressive symptoms.

Methods

This single-centre, triple-blind, placebo-controlled randomised clinical trial included adult patients with depression scheduled for inpatient surgery. After surgery, patients were randomly allocated to receive ketamine (0.5 mg kg^-1 over 10 min followed by 0.3 mg kg^-1 h^-1 for 3 h) or an equal volume of normal saline. Depressive symptoms were measured using the Montgomery-Asberg Depression Rating Scale. On post-infusion day 1, participants guessed which

SUBMITTER: Fritz BA 

PROVIDER: S-EPMC10764255 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature