Identification of ZIP8-induced ferroptosis as a major type of cell death in monocytes under sepsis conditions.

ABSTRACT: Sepsis is a heterogenous syndrome with concurrent hyperinflammation and immune suppression. A prominent feature of immunosuppression during sepsis is the dysfunction and loss of monocytes; however, the major type of cell death contributing to this depletion, as well as its underlying molecular mechanisms, are yet to be identified. In this study, we confirmed the monocyte loss in septic patients based on a pooled gene expression data of periphery leukocytes. Using the collected reference gene sets from databases and published studies, we identified ferroptosis with a greater capacity to distinguish between sepsis and control samples than other cell death types. Further investigation on the molecular drivers, by a genetic algorithm-based feature selection and a weighted gene co-expression ne

SUBMITTER: Zhang T 

PROVIDER: S-EPMC10764267 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature