Bioactive glycans in a microbiome-directed food for children with malnutrition.

ABSTRACT: Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition^1-4. Here we analyse biospecimens from a randomized, controlled trial of a microbiome-directed complementary food (MDCF-2) that produced superior rates of weight gain compared with a calorically more dense conventional ready-to-use supplementary food in 12-18-month-old Bangladeshi children with moderate acute malnutrition⁴. We reconstructed 1,000 bacterial genomes (metagenome-assembled genomes (MAGs)) from the faecal microbiomes of trial participants, identified 75 MAGs of which the abundances were positively associated with ponderal growth (change in weight-for-length Z score (WLZ)), characterized changes in MAG gene expression as a function of tre

SUBMITTER: Hibberd MC 

PROVIDER: S-EPMC10764277 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature