Cytoneme-mediated transport of active Wnt5b-Ror2 complexes in zebrafish.

ABSTRACT: Chemical signalling is the primary means by which cells communicate in the embryo. The underlying principle refers to a group of ligand-producing cells and a group of cells that respond to this signal because they express the appropriate receptors^1,2. In the zebrafish embryo, Wnt5b binds to the receptor Ror2 to trigger the Wnt-planar cell polarity (PCP) signalling pathway to regulate tissue polarity and cell migration^3,4. However, it remains unclear how this lipophilic ligand is transported from the source cells through the aqueous extracellular space to the target tissue. In this study, we provide evidence that Wnt5b, together with Ror2, is loaded on long protrusions called cytonemes. Our data further suggest that the active Wnt5b-Ror2 complexes form in the producing

SUBMITTER: Zhang C 

PROVIDER: S-EPMC10764289 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature