Unraveling the link: locomotor activity exerts a dual role in predicting Achilles tendon healing and boosting regeneration in mice.

ABSTRACT:

Introduction

Tendon disorders present significant challenges in the realm of musculoskeletal diseases, affecting locomotor activity and causing pain. Current treatments often fall short of achieving complete functional recovery of the tendon. It is crucial to explore, in preclinical research, the pathways governing the loss of tissue homeostasis and its regeneration. In this context, this study aimed to establish a correlation between the unbiased locomotor activity pattern of CRL:CD1 (ICR) mice exposed to uni- or bilateral Achilles tendon (AT) experimental injuries and the key histomorphometric parameters that influence tissue microarchitecture recovery.

Methods

The study involved the phenotyping of spontaneous and voluntary locomotor activity patterns in male mice using di

SUBMITTER: Faydaver M 

PROVIDER: S-EPMC10764449 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature