Nomograms containing body dose parameters for predicting survival in patients with nasopharyngeal carcinoma.

ABSTRACT:

Purpose

To assess the impact of body dose on survival outcomes in nasopharyngeal carcinoma (NPC) patients and to create novel nomograms incorporating body dose parameters for predicting survival.

Methods

594 of non-metastasis NPC patients (training group, 396; validation group, 198) received intensity-modulated radiation therapy at our institution from January 2012 to December 2016. Patient characteristics, body dose parameters in dose-volume histogram (DVH) and hematology profiles were collected for predicting overall survival (OS) and progression-free survival (PFS). Nomograms for OS and PFS were developed using the selected predictors. Each nomogram was evaluated based on its C-index and calibration curve.

Results

Body dose-based risk score for OS (RS_OS)

SUBMITTER: Jiang J 

PROVIDER: S-EPMC10764493 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature