Testosterone affects type I/type II interferon response of neutrophils during hepatic amebiasis.

ABSTRACT: Differences in immune response between men and women may influence the outcome of infectious diseases. Intestinal infection with Entamoeba histolytica leads to hepatic amebiasis, which is more common in males. Previously, we reported that innate immune cells contribute to liver damage in males in the murine model for hepatic amebiasis. Here, we focused on the influences of sex and androgens on neutrophils in particular. Infection associated with neutrophil accumulation in the liver was higher in male than in female mice and further increased after testosterone treatment in both sexes. Compared with female neutrophils, male neutrophils exhibit a more immature and less activated status, as evidenced by a lower proinflammatory N1-like phenotype and deconvolution, decreased gene expression of

SUBMITTER: Er-Lukowiak M 

PROVIDER: S-EPMC10764495 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature