Preeclampsia, antihypertensive medication use in pregnancy and risk of childhood cancer in offspring.

ABSTRACT:

Purpose

Preeclampsia is a serious pregnancy complication that presents a significant risk to both the mother and the fetus. Preeclampsia and medications associated with its treatment are potentially linked to increased childhood cancer risk. Therefore, we examined the association between preeclampsia, antihypertensive medications, and childhood cancer in offspring.

Methods

Cases (n = 6,420) and controls (n = 160,484) were obtained from Danish national registries. We performed conditional logistic regression analyses to estimate the association between preeclampsia and childhood cancer risk, and examined the effects of antihypertensive medication use in pregnancy in relation to childhood cancer risk in the offspring with adjustment for relevant covariates.

Results

We o

SUBMITTER: Askins L 

PROVIDER: S-EPMC10764520 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature