Application of Mendelian randomization to assess host gene-gut microbiota correlations in patients with esophageal cancer.

ABSTRACT:

Background

Increasing evidence suggests that esophageal cancer (ESCA) may be correlated with gut flora. However, their causal connection remains unclear. This study aimed to evaluate potential causal linkages and gene-gut microbiome associations between the gut microbiota and ESCA using Mendelian randomization (MR).

Methods

We analyzed the data using genome-wide association studies. The exposure factor and outcome variable were the gut microbiota and ESCA, respectively. The MR-Egger method, weighted median, inverse-variance weighted method, heterogeneity test, sensitivity analysis, and multiplicity analysis were used for the MR analysis. And it was validated using an external dataset. Further meta-analysis was performed to validate the robustness of this relationship. Finall

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10764629 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature