Early parental deprivation during primate infancy has a lifelong impact on gene expression in the male marmoset brain.

ABSTRACT: Adverse early life experiences are well-established risk factors for neurological disorders later in life. However, the molecular mechanisms underlying the impact of adverse experiences on neurophysiological systems throughout life remain incompletely understood. Previous studies suggest that social attachment to parents in early development are indispensable for infants to grow into healthy adults. In situations where multiple offspring are born in a single birth in common marmosets, human hand-rearing is employed to ensure the survival of the offspring in captivity. However, hand-reared marmosets often exhibit behavioral abnormalities, including abnormal vocalizations, excessive attachment to the caretaker, and aggressive behavior. In this study, comprehensive transcriptome analyses were

SUBMITTER: Shinohara H 

PROVIDER: S-EPMC10764730 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature