Role of the mechanical microenvironment on CD-44 expression of breast adenocarcinoma in response to radiotherapy.

ABSTRACT: The biological effects of ionizing radiation are exploited in the clinical practice of radiotherapy to destroy tumour cells while sparing the surrounding normal tissue. While most of the radiotherapy research focused on DNA damage and repair, recently a great attention is going to cells' interactions with the mechanical microenvironment of both malignant and healthy tissues after exposure. In fact, the stiffness of the extracellular matrix can modify cells' motility and spreading through the modulation of transmembrane proteins and surface receptors' expression, such as CD-44. CD-44 receptor has held much interest also in targeted-therapy due to its affinity with hyaluronic acid, which can be used to functionalize biodegradable nanoparticles loaded with chemotherapy drugs for targeted ther

SUBMITTER: Frascogna C 

PROVIDER: S-EPMC10764959 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature