Gut microbiota associated with appetite suppression in high-temperature and high-humidity environments.

ABSTRACT:

Background

Food is crucial for maintaining vital human and animal activities. Disorders in appetite control can lead to various metabolic disturbances. Alterations in the gut microbial composition can affect appetite and energy metabolism. While alterations in the gut microbiota have been observed in high-temperature and high-humidity (HTH) environments, the relationship between the gut microbiota during HTH and appetite remains unclear.

Methods

We utilised an artificial climate box to mimic HTH environments, and established a faecal bacteria transplantation (FMT) mouse model. Mendelian randomisation (MR) analysis was used to further confirm the causal relationship between gut microbiota and appetite or appetite-related hormones.

Findings

We found that, in the eighth

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10765014 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature