Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia.

ABSTRACT:

Importance

Hypertensive disorders of pregnancy (HDPs), including gestational hypertension and preeclampsia, are important contributors to maternal morbidity and mortality worldwide. In addition, women with HDPs face an elevated long-term risk of cardiovascular disease.

Objective

To identify proteins in the circulation associated with HDPs.

Design, setting, and participants

Two-sample mendelian randomization (MR) tested the associations of genetic instruments for cardiovascular disease-related proteins with gestational hypertension and preeclampsia. In downstream analyses, a systematic review of observational data was conducted to evaluate the identified proteins' dynamics across gestation in hypertensive vs normotensive pregnancies, and phenome-wide MR analyses were p

SUBMITTER: Schuermans A 

PROVIDER: S-EPMC10765315 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature