High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial.

ABSTRACT: Rationale: The effects of high-dose inhaled nitric oxide on hypoxemia in coronavirus disease (COVID-19) acute respiratory failure are unknown. Objectives: The primary outcome was the change in arterial oxygenation (Pa_O2/Fi_O2) at 48 hours. The secondary outcomes included: time to reach a Pa_O2/Fi_O2.300mmHg for at least 24 hours, the proportion of participants with a Pa_O2/Fi_O2.300mmHg at 28 days, and survival at 28 and at 90 days. Methods: Mechanically ventilated adults with COVID-19 pneumonia were enrolled in a phase II, multicenter, single-blind, randomized controlled parallel-arm trial. Participants in the intervention arm received inhaled

SUBMITTER: Di Fenza R 

PROVIDER: S-EPMC10765403 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature