Low dietary fiber intake impairs small intestinal Th17 and intraepithelial T cell development over generations.

ABSTRACT: Dietary fiber strongly impacts the microbiota. Here, we show that a low-fiber diet changes the small intestinal (SI) microbiota and impairs SI Th17, TCRαβ⁺CD8αβ⁺ and TCRαβ⁺CD8αα⁺ intraepithelial T cell development. We restore T cell development with dietary fiber supplementation, but this defect becomes persistent over generations with constant low-fiber diets. Offspring of low-fiber diet-fed mice have reduced SI T cells even after receiving a fiber-rich diet due to loss of bacteria important for T cell development. In these mice, only a microbiota transplant from a fiber-rich diet-fed mouse and a fiber-rich diet can restore T cell development. Low-fiber diets reduce segmented filamentous bacteria (SFB) abundance, impairing its vertical transmiss

SUBMITTER: Royer CJ 

PROVIDER: S-EPMC10765424 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature