Effect of intracranial electrical stimulation on dynamic functional connectivity in medically refractory epilepsy.

ABSTRACT:

Objective

The objective of this study was to explore the distributed network effects of intracranial electrical stimulation in patients with medically refractory epilepsy using dynamic functional connectivity (dFC) and graph indicators.

Methods

The time-varying connectivity patterns of dFC (state-based metrics) as well as topological properties of static functional connectivity (sFC) and dFC (graph indicators) were assessed before and after the intracranial electrical stimulation. The sliding window method and k-means clustering were used for the analysis of dFC states, which were characterized by connectivity strength, occupancy rate, dwell time, and transition. Graph indicators for sFC and dFC were obtained using group statistical tests.

Results

DFCs were clu

SUBMITTER: Lu M 

PROVIDER: S-EPMC10765510 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature