Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.

ABSTRACT: Progression through the cell cycle is controlled by regulated and abrupt changes in phosphorylation¹. Mitotic entry is initiated by increased phosphorylation of mitotic proteins, a process driven by kinases², whereas mitotic exit is achieved by counteracting dephosphorylation, a process driven by phosphatases, especially PP2A:B55³. Although the role of kinases in mitotic entry is well established, recent data have shown that mitosis is only successfully initiated when the counterbalancing phosphatases are also inhibited⁴. Inhibition of PP2A:B55 is achieved by the intrinsically disordered proteins ARPP19^5,6 and FAM122A⁷. Despite their critical roles in mitosis, the mechanisms by which they achieve PP2A:B55 inhibition is unkno

SUBMITTER: Padi SKR 

PROVIDER: S-EPMC10765524 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature