High-dose vitamin D₃ supplementation shows no beneficial effects on white blood cell counts, acute phase reactants, or frequency of respiratory infections.

ABSTRACT:

Background

Vitamin D has been suggested to influence the immune system, and vitamin D metabolites and the vitamin D receptor (VDR) are generated and expressed in white blood cells (WBC). Moreover, vitamin D status has been associated with incidence and prognosis of some respiratory tract infections (RTI). Therefore, we investigated the effect of vitamin D₃ supplementation on WBC, acute phase reactants (APR), and the risk of developing RTIs.

Methods

A double-blinded, randomized, placebo-controlled clinical trial of 307 infertile men with multiple secondary immunological endpoints. The vitamin D₃ group (n = 151) initially received 300,000 IU (7,500 µg) cholecalciferol once - followed by 1,400 IU (35 µg) daily for 150 days. The placebo group (n = 156) did

SUBMITTER: Wall-Gremstrup G 

PROVIDER: S-EPMC10765571 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature