Personalized antibiotic selection in periodontal treatment improves clinical and microbiological outputs.

ABSTRACT:

Introduction

Periodontitis is a biofilm-mediated disease that is usually treated by non-surgical biofilm elimination with or without antibiotics. Antibiotic treatment in periodontal patients is typically selected empirically or using qPCR or DNA hybridization methods. These approaches are directed towards establishing the levels of different periodontal pathogens in periodontal pockets to infer the antibiotic treatment. However, current methods are costly and do not consider the antibiotic susceptibility of the whole subgingival biofilm.

Methods

In the current manuscript, we have developed a method to culture subgingival samples ex vivo in a fast, label-free impedance-based system where biofilm growth is monitored in real-time under exposure to different antibiotics,

SUBMITTER: Ziemyte M 

PROVIDER: S-EPMC10765594 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature