Commonly disrupted pathways in brain and kidney in a pig model of systemic endotoxemia.

ABSTRACT: Sepsis is a life-threatening state that arises due to a hyperactive inflammatory response stimulated by infection and rarely other insults (e.g., non-infections tissue injury). Although changes in several proinflammatory cytokines and signals are documented in humans and small animal models, far less is known about responses within affected tissues of large animal models. We sought to understand the changes that occur during the initial stages of inflammation by administering intravenous lipopolysaccharide (LPS) to Yorkshire pigs and assessing transcriptomic alterations in the brain, kidney, and whole blood. Robust transcriptional alterations were found in the brain, with upregulated responses enriched in inflammatory pathways and downregulated responses enriched in tight junction and bloo

SUBMITTER: Olney KC 

PROVIDER: S-EPMC10765757 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature