Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice.

ABSTRACT:

Background

Major depressive disorder (MDD) is a common but severe psychiatric illness characterized by depressive mood and diminished interest. Both nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 1 (NLRP1) inflammasome and autophagy have been reported to implicate in the pathological processes of depression. However, the mechanistic interplay between NLRP1 inflammasome, autophagy, and depression is still poorly known.

Methods

Animal model of depression was established by chronic social defeat stress (CSDS). Depressive-like behaviors were determined by social interaction test (SIT), sucrose preference test (SPT), open field test (OFT), forced swim test (FST), and tail-suspension test (TST). The protein expression levels of NLRP1 inf

SUBMITTER: Zhu YJ 

PROVIDER: S-EPMC10765763 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature