CD147 induces asthmatic airway remodeling and activation of circulating fibrocytes in a mouse model of asthma.

ABSTRACT:

Background

Airway remodeling is a poorly reversible feature of asthma which lacks effective therapeutic interventions. CD147 can regulate extracellular matrix (ECM) remodeling and tissue fibrosis, and participate in the pathogenesis of asthma. In this study, the role of CD147 in airway remodeling and activation of circulating fibrocytes was investigated in asthmatic mice.

Methods

Asthmatic mouse model was established by sensitizing and challenging mice with ovalbumin (OVA), and treated with anti-CD147 or Isotype antibody. The number of eosinophils in bronchoalveolar lavage fluid (BALF) was examined by microscope, and the levels of interleukin-4 (IL-4), IL-5 and IL-13 in BALF were detected by enzyme-linked immunosorbent assay (ELISA). The number of CD45⁺ and collag

SUBMITTER: Li Z 

PROVIDER: S-EPMC10765784 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature