A combination of mild-moderate hypoxemia and low compliance is highly prevalent in persistent ARDS: a retrospective study.

ABSTRACT:

Background

The Acute Respiratory Distress Syndrome (ARDS) is characterized by lung inflammation and edema, impairing both oxygenation and lung compliance. Recent studies reported a dissociation between oxygenation and compliance (severe hypoxemia with preserved compliance) in early ARDS and COVID-19-related-ARDS (CARDS). During the pandemic, in patients requiring prolonged mechanical ventilation, we observed the opposite combination (mild-moderate hypoxemia but significantly impaired compliance). The purpose of our study was to investigate the prevalence of this combination of mild-moderate hypoxemia and impaired compliance in persistent ARDS and CARDS.

Methods

For this retrospective study, we used individual patient-level data from two independent cohorts of ARDS patients.

SUBMITTER: Papoutsi E 

PROVIDER: S-EPMC10765810 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature